脑缺血损伤的炎症反应及治疗策略展望

Post-ischemic inflammation and therapeutic strategy

研究表明炎症反应在脑缺血损伤中发挥重要作用。脑缺血损伤诱导的炎症反应是一个复杂的动态过程,包括一系列炎症细胞和炎症因子的参与。脑缺血诱导促炎症介质表达,促进白细胞浸润,激活脑内的小胶质细胞和星形胶质细胞,产生炎症反应,加重脑损伤。脑缺血损伤的炎症机制研究为临床寻找有效的治疗方法提供了重要的思路。本文从基础研究和临床试验方面简单阐述了参与脑缺血损伤炎症反应的几类研究较多的炎症细胞和促炎症介质,并探讨了针对脑缺血损伤中炎症反应的治疗方案及其应用前景。

Studies show that inflammation plays an important role in cerebral ischemic injury. Post- ischemic inflammation is a dynamic process involving a complicated set of interactions among various inflammatory cells and molecules, It is a consequence of infiltration of peripheral inflammatory cells into the brain and activation of glial cells and resident macrophages. Inflammation contributes to the late stages of ischemic injury, alleviates neuronal survival and results in worsening of neurologic outcome. Studies on the mechanism of post-ischemic inflammation are yielding insight into therapeutic strategies for ischemic stroke. This review focuses on the main inflammatory cells and proinflammatory factors involved in the post-ischemic inflammation, as well as the promising therapeutic strategies.