格氏反应制备1-甲基-2-对甲苯甲酰基吡咯

Synthesis of (1-methyl-1H-pyrrol-2-yl)(p-tolyl)methanone by the gringnard Reaction

本文介绍了一种制备1-甲基-2-对甲苯甲酰基吡咯的方法,该方法以N-甲基吡咯为起始原料,先经过Vils-meier-haack甲酰化反应制得N-甲基-2-吡咯醛,后者经肟化脱水制得N-甲基-2-吡咯腈,该化合物与格氏试剂对甲苯基溴化镁发生格氏反应,经水解得到1-甲基-2-对甲苯甲酰基吡咯.在格氏反应中,尝试使用超声波辐射的方法,取得了较好的效果.经过工艺改进,各步反应均达到了较高的收率,总收率达到30.5%,同时对实验中的有关问题做了详细的探讨.

In this paper, a novel synthesis method of （ 1 -methyl- 1H-pyrrol- 2-yl ） （ p-tolyl ） Methanoneis described. N-methyl- 2-pyrrolealdehyde was prepared through Vilsmeier-haack reaction of N-methylpyrrole, then this aldehyde was converted to N- methyl- 2-pyrrolecarbonitrile through oximation and dehydration. Finally, （ 1 -methyl- 1H-pyrrol- 2-yl ） （ p-tolyl ） methanone was prepared through Grignard reaction of p-tolylMgBr with N-methyl-2-pyrrolecarbonitrile. In the Grignard reaction, a better result was obtained under ultrasound irradiation. The total yield of preparation amounted to 30.5 %. , and the related problems in the experiment was discussed.