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气相色谱法直接测量^(18)F-FDG中Kryptofix 2.2.2的含量 被引量：14

Direct Measurement of Kryptofix 2.2.2 in ^(18)F-FDG by Gas Chromatography
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摘要 以OV-101型毛细管作为分离柱,利用氢火焰检测器(FID)和氮磷检测器(NPD),采用气相色谱法检测了18F-脱氧葡萄糖(18F-FDG)中的Kryptofix 2.2.2。结果显示,氨基聚醚Kryptofix 2.2.2在分离柱的保留时间为2.4 min,最低检测水平为0.50 mg/L。30批次本中心常规制备的18F-FDG中Kryptofix 2.2.2含量检测值为1.10±0.15 mg/L;10批没有应用AG50型树脂吸附的平均含量检测值为106.0±21.0 mg/L。以上结果表明,应用气相色谱法对Kryptofix 2.2.2可以进行快速、高灵敏度检测,其检测灵敏度比TLC法高出50倍;同时可直接测量,排除其他杂质的干扰;该方法可推广应用于18F-FDG和其它18F亲核标记正电子药物的日常质量控制检测。 Kryptofix 2.2.2 in ^18F-FDG preparation is analized by gas chromatography coupled with OV-101 capillary column, and nitrogen-selective detector （NPD） and FID. Its retention time is 2.4 min from the column, and detected at the levels as low as 0.50 mg/L; the average residual of 30 normal batchs are 1.10±0.15 mg/L （n= 30）. Direct measurement of Kryptofix 2.2.2 in routine ^18F-FDG preparation is effective using Gas Chromatography with a high sensitivity （50 times better than TLC method） for the daily quality control of ^18 F-FDG.
作者 花宁 陈立光
机构地区 广州市原子高科同位素医药有限公司 广东省人民医院PET中心
出处 《同位素》 CAS 北大核心 2007年第2期105-107,97,共4页 Journal of Isotopes
关键词 ^18F-FDG Kryptofix 2.2.2 气相色谱 ^18F-FDG Kryptofix 2.2.2 gas chromatography
分类号 TQ463.7 [化学工程—制药化工] O657.7 [理学—分析化学]
  • 相关文献

参考文献10

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共引文献10

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引证文献14

二级引证文献26

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