马齿苋治疗蜂毒过敏反应的实验研究

Study on treatment of Portulaca oleracea. L on anaphylaxis by bee venom

目的以蜂针针刺动物足部使出现红肿热痛等局部过敏反应症状,建立峰针疗法所致局部过敏反应的动物模型,比较马齿苋不同给药方式对蜂毒过敏动物的抗炎作用、镇痛作用及解热作用大小,为马齿苋临床上用于治疗蜂针疗法引起的过敏反应提供依据。方法以抗炎试验、镇痛试验、解热试验为主要试验方法,考察马齿苋水煎液口服给药、泡洗给药、口服兼泡洗给药对蜂毒引起的动物过敏反应的治疗作用。结果与模型对照组比较,给药组、泡洗给药组及口服兼泡洗给药组对蜂针引起局部过敏反应均有显著抑制作用(P<0.05或P<0.01);与口服给药组、泡洗给药组比较,口服兼泡洗给药组抑制作用最强(P<0.05)。结论提示中药马齿苋对蜂毒引起的局部过敏反应具有较强治疗作用,且给药方式不同其治疗作用强度不同。

OBJECTIVE To establish an animal model of local anaphylaxis in the therapy of bee acupuncture by makin mice flare and thermalgia with stinging on its foot, and to compare the anti-inflammatory effect, analgesic effect and relieving fever effect on mice when they were dosed Portulaca oleracea L in different ways. METHODS Anti-inflammatory experiment, analgesia experiment, and relieving experiment were applied to compare the cure effets of Portulaca oleracea. L to anaphylaxis by bee venom when the mice were dosed by mouth, by steeping and by both of them. RESULTS The effect of oral group, bathing group, and both oral and bathing group were stronger than model control group （P 〈 0. 05 of P 〈 0. 01 ） ）, and the effect of both oral and bathing group was stronger than oral group and bathing group（P 〈 0. 05 ）. CONCLUSION Portulaca oleracea L showed a marked cure effect of local anaphylaxis of bee venom,and the effects were different in various dosage wavs.