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脂必妥(60例)与辛伐他汀(30例)治疗高脂血症的比较 被引量:20

Zhi-bi-tuo vs simvastatin in treating hyperlipidemia
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摘要 目的:比较脂必妥与辛伐他汀治疗高脂血症的疗效。方法:高脂血症病人60例(男性28例,女性32例,年龄55±s8a)服用脂必妥3片(0.35g/片),po,tid,连续4wk;另30例(男性14例,女性16例,年龄56±9a)用辛伐他汀1片(5mg/片),po,qd,连续4wk。结果:2组均能降低血TC,TG及升高HDL-ch,脂必妥组依次下降20%,40%及HDL-ch升高29%;辛伐他汀组为下降20%,39%,升高28%。组间比较无显著差异,2组均仅有轻微不良反应。结论:脂必妥与辛伐他汀治疗高脂血症的疗效与安全性相似。 AIM: To compare the antilipidemia effect of Zhi-bi-tuo and simvastatin. METHODS: Sixty patients (M 28, F 32, age 55±s 8 a) with hyperlipidemia were treated with Zhi-bi-tuo 3 Tab (0.35 g/Tab), po, tid, for 4 wk, other 30 patients (M 14, F 16, age 56±9 a) received simvastatin 1 Tab (5 mg/tab), po, qd, for 4 wk. RESULTS: Both drugs were equally effective in lowing TC, TG and increasing HDL-ch. Zhi-bi-tuo group: TC-20%, TG-40%, HDL-ch+29%. Simvastatin group: TC-20%, TG-39%, HDL-ch+28%. Which had no significant difference between two groups (P>0.05). Adverse reaction of two group are all mild. CONCLUSION: Zhi-bi-tuo is an effective and safe drug in treating hyperlipidemia as well as simvastatin.
出处 《新药与临床》 CSCD 北大核心 1997年第1期63-64,共2页
关键词 脂必妥 辛伐他汀 高脂血症 药物疗法 Zhi-bi-tuo simvastatin hypercholesterolemia hypertriglyceridemia lipoproteins
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