甘精胰岛素的临床评价

Clinical evaluation of insulin glargine

甘精胰岛素是由DNA重组技术制备的一种重组人胰岛素类似物,为长效降糖药。甘精胰岛素的作用较为平稳,血浓度无峰值,作用时间持久(可达24h)。因此,每天1次剂量如同生理基础胰岛素。甘精胰岛素的不良反应主要为低血糖,但其夜间低血糖的发生率明显低于其他某些胰岛素制剂。

Insulin glargine produced by recombinant DNA technology is a recombinant human insulin analog that is a long-acting blood-glucose-lowing agent. The effect profile of insulin glargine was relatively constant with no pronounced peak, and the duration of its effects was prolonged （up to 24 hours）. This profile allows once-daily dosing as a normal basal insulin, the principal adverse reaction to insulin glargine is hypoglycemia, but lower incidence of nocturnal hypoglycemia is more apparent with insulin glargine compared with some other insulin preparations.