抗抑郁焦虑药物治疗功能性消化不良

Treatement of functional dyspepsia with antidepressant and anxiolytic drugs

目的探讨抗抑郁、焦虑药物治疗功能性消化不良(FD)疗效。方法83例FD患者经SDS、SAS测定,分为抑郁焦虑组与单纯FD组,均为黛力新或百优解治疗4周,记录疗效与副作用。结果抑郁焦虑组总有效率92.3%,单纯FD组总有效率84.1%,二者疗效无显著差异,百优解、黛力新治疗FD疗效相似。结论FD发病与精神因素关系密切,短期应用抗抑郁、焦虑药物治疗FD疗效肯定,耐受性尚可。

Objective To evaluate the efficacy and safety of antidepressant and anxiolytic drugs in the treatment of functional dyspepsia （FD）. Methods Eighty-three outpatients of FD were selected between Jul 2003 and Dec 2005. Diagnoses of FD was made according to the Rome Ⅱcriteria. Self-Rating Depression Scale （SDS） and Self - Rating Anxiety Scale （SAS） were taken to divide the patients into two groups, the group of FD complicated with depression or anxiety （group 1 ） , and the group of simple FD （group 2）. Deanxit or Prozac was administered for 4 weeks in both groups. Symptoms were evaluated before and after the treatment. Therapeutic efficacy was analyzed, and adverse events were recorded. Results Forty-four patients were allotted to group 1, and 39 to group 2. Total efficacy of antidepressant and anxiolytic drugs was 92. 3% and 84. 1% in group 1 and 2, respectively, without significant difference （p = 0.418）. Efficacy of Deanxit and Prozae in the treatment of FD was similar. Incidence of adverse events was 14.5% , including dizziness, thirsty, nausea, constipation and insomnia. Conclusion The pathogenesis of FD is closely related to psychic factors. Short-term treatment of FD with antidepressants and anxiolytics is efficacious and tolerable.