黄甘草异黄酮成分的研究

ISOFLAVONES FROM GLYCYRRHIZA EURYCARPA

从黄甘草（ＧｌｙｃｙｒｒｈｉｚａｅｕｒｙｃａｒｐａＰ．Ｃ．Ｌｉ）根及根茎中分得五个异黄酮化合物，根据理化性质及光谱（ＵＶ，ＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ，ＮＯＥ，ＨＭＢＣ）数据分析，化合物Ｉ的结构推定为７，２′，４′三羟基３′异戊烯基异黄酮，为一新化合物，命名为黄甘草异黄酮Ａ（ｅｕｒｙｃａｒｐｉｎＡ）。化合物Ｉ的结构推定为７，２′二羟基（２″，３″∶４′，３′）６″，６″二甲基吡喃异黄酮，为一新的天然产物，命名为黄甘草异黄酮Ｂ（ｅｕｒｙｃａｒｐｉｎＢ）。其余化合物分别鉴定为ｌｉｃｏｉｓｏｆｌａｖｏｎｅＡ（ＩＩＩ），毛蕊异黄酮（ｃａｌｙｃｏｓｉｎ，ＩＶ）和芒柄花素（ｆｏｒｍｏｎｏｎｅｔｉｎ，Ｖ）。化合物ＩＩ～Ｖ均为首次从本植物中得到。

A new isoflavone, named eurycarpin A and a new natural product isoflavone named eurycarpin B have been isolated from the roots of Glycyrrhiza eurycarpa P.C.Li. Their structures were determined to be 7,2′,4′ trihydroxy 3′ (3,3 dimethylallyl) isoflavone(I) and 7,2′ dihydroxy 6″,6″ dimethylpyrano (2″,3″∶4′,3′)isoflavone(II) on the basis of spectroscopic analysis (UV,EI MS, 1HNMR, 13 CNMR, NOE difference and HMBC). In addition, three known isoflavones, licoisoflavone A, calycosin and formononetin, were obtained for the first time from this plant.