癌旁组织CD44v mRNA的表达对原发性肝癌术后复发的影响

Influence of expression of splice variants of CD44 in tumor-adjacent tissue upon the recurrence of primary liver cancer after operation

目的:研究原发性肝癌癌旁组织CD44vmRNA表达的意义。方法：应用RT－PCR检测原发性肝癌瘤旁组织CD44vmRNA的表达并结合术后近2年的随访结果进行综合分析。结果：癌旁组织CD44vmRNA表达高于癌组织者的肿瘤包膜缺如、门静脉癌栓和瘤周卫星结节等与转移相关的病理指标高于癌旁组织CD44vmRNA表达低于癌组织的病例，前者复发率亦高于后者（P＜0．05）。结论：癌旁组织CD44vmRNA的表达在评价肝癌侵袭转移潜能以及预测其复发等方面是一个较癌组织本身CD44vmRNA的表达更为有用的指标。

To study the significance of the expression of splice variants of CD44 (CD44v) in tu-m0r-adjacent tissue of the patients with primary liver cancer(PLC). Methods: To research into the signifi-cance of the expression of CD44v mRNA in tumor-adjacent tissue of 30 patients with PLC by RT-PCR andfollow-up. Results: In the patients that the expression of CD44v mRNA of tumor-adjacent tissue washigher than those of tumor tissue(group I ), clinical pathological indexes were higher than in the patientsthat the expression of CD44v mRNA was higher than the tumor tissue(group I ). The recurrent rate ofgroup I was higher than that of group n (P<0. 05). Conclusion: For eva1uating the metastatic potentialand recurrence of PLC, the expression of CD44v in tumor-adjacent tissue may be a m0re useful indicatorthan those in tumor tissue itself.