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毛细管区带电泳拆分肾上腺素类药物 被引量:7

Research of separation of enantiomers of adrenalines by capillary zone eletrophoresis
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摘要 考察各种因素对β-环糊精及其衍生物分离肾上腺素类药物的影响。采用毛细管区带电泳法(CZE)对去甲肾上腺素、肾上腺素和异丙肾上腺素的手性分离进行研究。未涂渍熔融石英毛细管50μm×58.5 cm(有效长度50 cm);温度20℃,操作电压30 kV,正极进样50 mbar×3 s,检测波长204 nm。β-环糊精(-βCD)及其两种衍生物作为手性选择剂。异丙肾上腺素得到了基线分离,肾上腺素和去甲肾上腺素未分离。 Capillary zone electrophoresis (CZE) has been used for the enantiomeric separation of the racemic isoprenaline, noradrenaline and adrenaline with bare fused silica capillary and employing β-cyclodextrin (β-CD) and β-cyclodextrin derivatives as the chiral selectors. Both the complexion and enantiomeric resolution were influenced by β-CD kind, CD concentration and pH of background electrolyte (BGE). The effects of the BGE kinds and concentrations on the enantiomeric separation were also investigated. The results showed that SBE-β-CD has stronger recognition than that of others for the chiral separation of the basic drugs under study. The CD concentrations and pH of BGE have strong influence on the efficiency of chiral separation. Both β-CD and β-yclodextrin derivatives could not give enantiomerit resolution for noradrenaline and adrenaline.
出处 《分析试验室》 CAS CSCD 北大核心 2007年第7期64-66,共3页 Chinese Journal of Analysis Laboratory
关键词 毛细管区带电泳 Β-环糊精 去甲肾上腺素 肾上腺素 异丙肾上腺素 手性拆分 Capillary zone electrophoresis β-cyclodextrin Noradrenaline Adrenaline Isoprenaline Chiral resolution
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