米非司酮配伍前列腺素终止大月份妊娠的临床应用

Clinic application of mifepristone on abortion in second trimester pregnancy

将１５０例妊娠８～２８周要求药物流产的妇女随机分成两组：米非司酮和米索前列醇口服给药组（ｎ＝１００），米非司酮和卡前列甲酯（ＰＧ０５）阴道给药组（ｎ＝５０）。观察其临床效果，孕周与流产效果及时间的关系，腹痛情况。结果：两组完全流产率分别为８８％和８４％；孕周１５～２８周组完全流产率为９２．４％，明显高于８～１４周组；流产所用时间长于８～１４周组；两组无腹痛和轻微腹痛者均占８５％以上。结论：米非司酮配伍前列腺素用于终止大月份妊娠安全、有效，有临床实用价值。

A hundred and fifty women in second trimester of pregnancy (8-28 week),who was requested medical abortion,were allocated into 2 groups at random.Mifepristone and 15 methyt PGF 2a vaginal supposition PGF 2x (PG 05 ) and misoprostrol oral (tablets) were given as the following 2 regimens:group Ⅰ ( n =100):mifepristone 50mg was given immediatedly,then 25mg b.i.d. (the amount of 200mg)+misoprostol 600μg q3h (total amount of 1800μg) on the 4th day;group Ⅱ ( n =50):mifeprstone 50mg was given immidiately,then 25mg b.i.d. (total amount of 200mg)+PG 05 1mg vaginal soppository q3h (total amount of 3mg) on the 4th day.As a results,the complete abortion rate of each group was 88% and 84% successively ( P > 0.01 ),but the complete abortion rate of 15￣28 pregnancy week was 92.4% and remarkablely higher than that of 8￣14 pregnancy week.In conclusion,the method is effective and safe and has practical value.