摘要
目的探讨胆囊结石与胆囊癌变的关系.方法1978年~1993年共收治原发性胆囊癌227例,男60例,女167例,年龄35岁~83岁,平均581岁.进行了组织病理学及临床资料回顾分析.结果胆囊癌合并胆囊结石83例,占366%,其中男性333%(20/60),女性377%(63/167)均明显高于胆结石自然发病率,并随年龄增长而有增高趋势,50岁以上者65例(783%),各年龄组间有显著差异,病理学结果显示,胆结石所致的粘膜异型增生可癌变;本组腺癌最多,共63例(887%).结论胆囊结石可诱发癌变,应施行选择性预防胆囊切除术.
AIM To study the relationship between gallbladder cancer and gallstone clinically. METHODS From 1978 to 1993, 227 patients with primary gallbladder cancer, (male 60, female 167; mean age 58 1, range 35~83 years) were retrospectively analysed clinically and histopathologically. RESULTS The ratio of gallstone in gallbladder cancer patients ( n =83), accounting for 36 6%, among them 33 3% for males (20/60), 37 7% for females (63/167) ,was higher than the morbidity of gallstone, and much higher in older peoples (63 patients were over 50 years of age, accounting for 78 3%). There was an obvious difference in different age groups. Pathologic results indicated that heterotypical hyperplasia of gallbladder mucosa could induce gallbladder cancer, and adenocarcinoma was most common in this series ( n =36, accounting for 88 7%). CONCLUSION Gallstone could induce cancer in some conditions, so selectively prophylactic cholecystectomy should be performed.
关键词
胆囊肿瘤
胆囊结石
Gallbladder neoplasms Cholelithiasis Adenocarcinoma Cholecystectomy