基于CFD技术的鼻腔输药的流动特性研究

An investigation on flow features of drug delivery through the human nasal cavity based on CFD

鼻腔输药作为一种新颖的输药方式,具有方便可靠的特点,不仅可以适用于局部而且适用于全身用药,已经受到广泛的重视。但由于人类的呼吸道复杂的立体结构使得鼻腔输药成为生物医药研究的一个长期的挑战。利用CFD(计算流体动力学,Computational Fluid Dynamics)技术对鼻腔输药的流动特性进行研究,对一个基于真实的人类鼻腔解剖的3D模型的输药的流动过程进行了分析,着重研究了不同的药物颗粒的流动和沉淀特性。利用CFD的商用软件FLUENT在层流情况下对不同的密度、直径和流动速率的药物颗粒在鼻腔中流动进行了数值模拟,并对计算结果进行了比较分析。CFD研究的结果为鼻腔输药这种新颖的药物输送方式的优化设计提供了依据。

Drug characteristic of Delivery through the Human Nasal Cavity is a new and innovative drug delivery system, with convenience and reliability, it already received the widespread attention, not only could it be suitable for partial medication but also the whole body. Drug delivery in the human respiratory tract is a long - standing challenge due to the complexity of the geometry and materials properties. This paper presents the flow features of Drug Delivery in the Human Nasal Cavity and simulates an airflow field based on a 3 D real - anatomical geometry of the human nasal cavity by Computational Fluid Dynamics （ CFD）, to research features of airflow field and deposition in the medicine transportation. Medicine particles transporting in a human nasal cavity under laminar flow conditions are simulated using FLUENT, a commercially available CFD software. We carded on the comparative analysis of the computed result under different value of particle density, diameter and flow rate. The CFD investigation results will be used to optimize design of novel drug delivery devices further through the human nasal cavity.