不同环境干预对局灶性脑梗死大鼠行为学恢复的影响

The effects of different environmental intervention on behavioral recovery in rats after unilateral local cerebral infarction

目的:研究独居、社会交往、探索学习和丰富环境对局灶性脑梗死大鼠行为学恢复的影响。方法:SD大鼠65只,采用开颅电凝法制作右侧大脑中动脉缺血(MCAO)模型,假手术组不电凝大脑中动脉,其余步骤与手术组相同。术后24h随机分为独居组(n=15)、社交组(n=15)、探索学习组(n=15)、丰富环境组(n=15)和假手术组(n=5),分别于术后第1、3、7、14、21、28d对大鼠采用Bederson神经功能评分及修订的神经功能评分(mNSS)进行评定。结果:Bederson神经功能评分及mNSS评分均显示探索学习组及丰富环境组在术后14—28d后明显优于独居组和社交组(P<0.05)。结论:环境对局灶性脑梗死大鼠的行为学恢复有明显影响,丰富环境及探索学习均能改善大鼠的预后。

Objective： To observe the effects of different environment intervention on behavioral recovery in rats after unilateral local cerebral infarction. Method： After the right middle cerebral artery occlusion （MCAO） with electric coagulation in SD rats, 65 male rats were randomly divided into individual living group, social communication group, learning group, enriched environment group and sham operated group. The behavioral recovery were evaluated with Bederson test and modified neurological severity scores （mNSS） test at the Ist, 3rd, 7th, 14th, 21st and 28th d after MCAO. Result： The scores of Bederson test and mNSS test in enriched environment group and learning group were better than those in individual living group and social communication group （P〈0.05） post operation 14d to 28d. Conclusion： Environment has effects on behavioral recovery in rats after unilateral local cerebral infarction, enriched environment and learning could improve the prognosis of rats.