新一代四环素类药物替加环素的研究进展

Research Development of Tigecycline:A New Glycylcycline Antimicrobial Agent

对于日益增多的危及生命的多药耐药菌的爆发与流行,临床上迫切需要新的抗生素,替加环素以其广谱、高效,较高的性价比,满足了人们这一需求。综述了近年来替加环素的研究进展,包括体内外的抗菌活性、抗生素后效应、药代动力学、不良反应、药物相互作用、临床研究、克服细菌耐药的机理、性价比等各个方面。替加环素是一个比较理想的药物,对大多数耐药菌都有较强的抑制力,适合于治疗复杂的具有耐药的感染。

New antimicrobial agents are urgently needed for clinical use due to the increasing prevalence and spread of multidrug-resistant bacteria that are commonly responsible for serious and life-threatening diseases. Tigecycline , an analogue of minocycline with additional properties of broad spectrum, high preformance, higher ratio of cost and effect, can satisfy the demand, the research development is review of tigecycline,included the antibacterial activity in and out of vivo, post antibiotics effect, pharmacokinetics, adverse effect, drug interaction, clinical research, overcome the mechanisms of overcome bacteria resistance, the ratio of cost and effect, etc. conclude, tigecycline is and idea drugs, have a good effect on the most of resistant bacteria, and fit for treatment of complicated and drug resistant infection.