女性2型糖尿病合并无症状性菌尿的临床相关因素研究

Study of risk factors in symptomatic bacteriuria in type 2 diabetic women

目的研究2型糖尿病女性患者无症状性菌尿(ASB)的患病情况及相关危险因素。方法用t检验和相关分析研究了62例女性非妊娠的糖尿病患者及与患者年龄、性别及月经状况相匹配的36例对照者的ASB的患病率及相关患病因素。ASB定义为至少1～2次尿菌培养菌落计数≥105cfu/ml。结果非妊娠女性2型糖尿病ASB患病率为12.9%,大肠杆菌为尿培养最常见的微生物,年龄、尿微量白蛋白与菌尿密切相关(P<0.05),而与糖尿病病程、血糖、HbAlc、血压、视网膜及神经病变无关。结论ASB在2型糖尿病女性患者的患病率是增高的,有必要在女性2型糖尿病的高龄、肾病患者中常规作尿培养。

Objective To study the prevalence and associates of asymptomatic bacteriuria（ASB） in women with type 2 diabetes mellitus.Methods 62 nonpregnant type 2 diabetic women（range：34 to 68 Associates for ASB was assessed and compared in participants with and without bacteriuria.Results ASB morbidity rate was 12.9% among diabetic women.E.coli was the most prevalent microorganism responsible for positive urine culture.Age and microalbuminuria had a meaningful relationship with bacteriuria（P〈0.01）,but no association was evident between duration of diabetes,nephropathy,HbAlc level and the presence of ASB.Conclusion The morbidity rate of ASB id higher in women with type 2 diabetes.Routine urine culture can be recommended for type 2 diabetic women elderly or complicated with diabetic nephropathy.