摘要
GATA转录因子是造血系统重要的调控因子。近年的研究发现,它不仅参与正常的造血调控,它的突变或异常表达还参与了血液系统疾病的发生和发展。现对GATA-1和GATA-2、GATA-3的突变和/或异常表达以及与之相关的血液系统疾病进行综述。
Transcription factors GATA are important regulating factors of hematopoietic system. Recently researchers discovered the GATA transcription factors are not only associated with the regulation of hematopoietic system, its mutation and aberrant expression are also linking to the proceed and development of hematological system diseases. This article mainly reviewed the relationship between the mutation and aberrant expression of GATA and hematologic system diseases.
出处
《细胞生物学杂志》
CSCD
2007年第4期493-496,共4页
Chinese Journal of Cell Biology
关键词
GATA转录因子
突变
表达
血液系统疾病
transcription factors GATA
mutation
expression
hematologic system diseases
