硫代硫酸钠涂剂的处方改进

Improvement of Formula of Sodium Thiosulfate Paint

目的:改进硫代硫酸钠涂剂的制备处方,使其更适用于临床。方法:改变《中国医院制剂规范》中硫代硫酸钠涂剂处方中硫代硫酸钠、乙醇用量,制备涂剂。结果与结论:改进后制剂成本降低,对皮肤刺激性减小,脱碘效果更好,值得推广。

OBJECTIVE ： To improve the formula of sodium thiosulfate paint so as to make it more adaptable to the clinical needs. METHODS： The sodium thiosulfate paint was prepared by adjusting the previous amount of sodium thiosulfate and ethanol in the sodium thiosulfate paint defined in Standard of Chinese Hospital Pharmaceutics. RESULT ＆ CONCLUSION： The improved preparation was more efficient in deiodination and with less skin irritation and lower cost, thus it worth to be widely used.