摘要
探讨凝血状态异常对糖尿病肾病发生、发展的影响。方法 采用放免法、双抗体夹心法,检测65例非胰岛素依赖性糖尿病(NIDDM)患者及15例正常人的血浆蛋白C(PC)、血浆血小板α-颗粒膜蛋白(GMP-140)及凝血因子Ⅷ:C、vWF。结果 (1)血浆PC在糖尿病微量白蛋白尿(DM_Ⅱ)组显著低于正常对照(C)组及糖尿病正常白蛋白尿(DM_Ⅰ)组;糖尿病临床蛋白尿(DM_Ⅲ)组更低;与尿白蛋白排泄率(UAER)呈负相关;(2)血浆GMP-140在DM_Ⅱ组显著高于C组及DM_Ⅰ组,而DM_Ⅲ组更高,与UAER呈正相关;(3)PC与GMP-140、Ⅷ:C、vWF呈负相关。结论 糖尿病肾病早期已显示高凝状态的存在,并可作为观察微血管病变的有价值指标。
To investigate the influence of abnormal blood coagulating state on development of diabetic nephropathy. Methods Using radioimmunoassay and bivanlent antibody sandwich technic, the levels of plasma protein C (PC), platelet alpha-granule membrane glycoprotein (GMP-140), and factor Ⅷ: C and vWF were detected in 65 NIDDM patients and 15 normal controls. Results (1)PC level in microalbuminuric patients(DMⅡ) was significantly lower than that in normal controls and in normoalbuminuric patients (DMⅠ ), the lowest was in clinical proteinuric patients (DMⅢ); PC levels correlated negatively with urinary albumin exeretion rates(UAER). (2)The GMP-140 level was higher signifi-antly in DMn than in normal controls and in DMⅢ ; and the highest was in DMⅠ; the GMP-140 levels positively correlated with UAER. (3)There were negative correlations between PC and GMP-140、Ⅷ C-vWF. Conclusion A hyper-coagulable state occurs early in diabetic nephropathy as valuable indexes in reflecting the microangiopathy in diabetes.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1997年第3期150-152,共3页
Chinese Journal of Nephrology
基金
辽宁省科学基金资助课题
关键词
糖尿病
肾病
血小板
α
颗粒膜蛋白
Diabetic nephropathy Protein C Platelet alpha-granule membrane glycoprotein