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磷酸川芎嗪脂质体大鼠在体鼻黏膜吸收研究 被引量:10

Study on In-vivo Nasal Mucosa Absorption of Tetramethylpyrazine Phosphate Liposome in Rats
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摘要 目的研究磷酸川芎嗪脂质体的鼻黏膜吸收特性。方法采用大鼠在体鼻腔循环灌流法,考察循环液流速、药物浓度对磷酸川芎嗪脂质体鼻黏膜吸收的影响,并对磷酸川芎嗪脂质体和磷酸川芎嗪溶液的鼻黏膜吸收进行比较。结果在流速为1.2~2.4mL/min范围内,磷酸川芎嗪脂质体鼻黏膜吸收速率常数随流速的增加而增加;在浓度为0.245~0.98mg/mL范围内,鼻黏膜吸收速率常数随浓度的增加而增加。与同浓度的磷酸川芎嗪溶液比较,脂质体吸收更快,鼻黏膜经时吸收量更高。结论磷酸川芎嗪脂质体比磷酸川芎嗪溶液鼻黏膜吸收更加完全。 Objective To study the characteristic of in - vivo nasal mucosa absorption of tetramethylpyrazine phosphate (TMPP) liposome in rats. Methods Nasal circulatory perfusion method in rats was used to study the effects of different circulatory rates and TMPP concentrations on nasal mucosa absorption of TMPP liposome. Nasal mucosa absorption rate constants of TMPP liposomes and TMPP solutions at the same concentration were also compared. Results The absorption rate constant of TMPP liposomes was increased with the increase of circulatory rates at the range of 1.2 - 2.4 mL/min and with the increase of TMPP concentrations at the range of 0. 245 -0.98 mg/mL. Both the absorption rate constant and ab- sorbed amount of TMPP for TMPP liposomes were higher than those for TMPP solutions at the same concentration. Conclusion The nasal mucosa absorption of TMPP liposome was complete as compared with that of TMPP solution.
出处 《中药新药与临床药理》 CAS CSCD 2007年第5期406-408,共3页 Traditional Chinese Drug Research and Clinical Pharmacology
基金 广州市科技攻关重点项目(2005Z2-D2021)
关键词 磷酸川芎嗪脂质体 鼻腔循环灌流法 鼻黏膜吸收 吸收速率常数 Tetramethylpyrazine phosphate(TMPP) liposome Nasal circulatory perfusion method Nasal mucosa absorption Absorption rate constant
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