摘要
目的观察奈替米星治疗高龄感染患者的安全性。方法选取急诊病房高龄感染患者40例,治疗前血清肌酐(Scr)均在正常范围内,内生肌酐清除率(Ccr)≥60 ml/min(按Cockcroft-Gault公式计算)。以奈替米星冻干粉针4 mg/(kg.d)加入糖水或盐水静脉滴注。感染一经确诊首先使用青霉素类、β-内酰胺类或大环内酯等抗菌药物治疗,3 d后如疗效不明显,则加用奈替米星联合治疗。于治疗前后检测尿微量白蛋白(MA)、尿α1-微球蛋白(Uα1-MG),奈替米星应用至稳态后检测其血谷浓度和峰浓度。抗生素使用前取痰、尿或褥疮分泌物做细菌学培养。结果Scr、Ccr、MA和Uα1-MG治疗前后差异无统计学意义。结论选择适宜人群,监测有效指标,准确评估老年人肾功能水平,联合应用抗生素奈替米星治疗高龄感染患者有效且安全。
Objective To evaluate the safety of netilmicin in the treatment of elderly patients with bacterial infections. Methods A total of 40 elderly patients with bacterial infection enrolled in the study,netilmicin was administered per day for 5 - 10 days at the daily dose of 4rag/（ kg·d） by intravenous drip. To ot）serve the changes of blood routine examination, urine routine examination Scr, MA, Uα1 - MG, Ccr, bacteria culture and adverse reactions before and after treatment. The drug＇s peak concentration and trough concentration were measured after 3 days of treatment. Results There was no difference for Scr,MA,Uα1 - MG, Ccr before and after treatment. Conclusion By the supervise of Scr, MA,Uα1 - MG,Ccr,it was recongnized that netilmicin is a safe and effective antibiotic in elderly patients with bacterial infection.
出处
《临床医学》
CAS
2007年第8期6-7,共2页
Clinical Medicine
关键词
奈替米星
高龄患者
肾功能
Netilmicin
Elderly patients
Renal function
