黄芪多糖对2-DM胰岛素抵抗大鼠血糖及血脂的影响

THE EFFECT OF APS TO FPG AND BLOOD LIPIDS ON INSULIN RESISTANCE OF RATS WITH TYPE 2 DIABETES

目的:研究黄芪多糖(Astragaluspolysaccharides,APS)对2型糖尿病(2-Diabetes;2-DM)胰岛素抵抗大鼠血糖及血脂的影响。方法:Wistar大鼠喂以高脂高糖饲料加小剂量链脲佐菌素(Streptozotocin,STZ)建立2型糖尿病早期胰岛素抵抗大鼠模型。将Wistar大鼠随机分为正常对照组、2-DM胰岛素抵抗模型对照组、黄芪多糖大剂量(800mg/kg/d)治疗组、黄芪多糖中剂量(400mg/kg/d)治疗组、黄芪多糖小剂量(200mg/kg/d)治疗组。检测了大鼠空腹血糖(fasting plasma glucose,FPG)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、胆固醇(CH)、的含量。结果:1、黄芪多糖能够显著降低2-DM胰岛素抵抗大鼠的血糖。2、黄芪多糖能显著降低2-DM胰岛素抵抗大鼠血清TG、CH、LDL含量,同时显著升高血清HDL含量。结论:黄芪多糖可以降低2型糖尿病胰岛素抵抗大鼠血糖和改善体内脂代谢紊乱。

Objective ：To investigate the effect of astragalus poly saccharides （APS） to FPG,blood lipids on insulin resistance of rats with type 2 diabetes. Methods：The rats model with Type 2 diabetes were induce by high calorie feeding and small dose injection of STZ . Wistar rats were randomly divided into group, diabetic model treated with APS （800mg/kg/d）, APS （400mg/kg/d）, APS （200mg/kg/d） and normal control group . the levels of FPG,TG,HDL,LDL,CH were medsured at the end of 12 weeks . Results： 1 ）APS can significanlg decrease the blood sugar of 2 - DM IR rats with insulin resistin . 2 ） APS can decrease the content of 2 - DM IR rats with insulin resistance while increase the contenet of the blood serum HDL. Conclusion：APS deconction can reduce FPG and blood lipids in 2 - DM IR rats.