2ZHANG Y , PROENCAR, MAFFEIM,et al.positional clonging of the mouse obese gene and its human homologue[J]. Nature, 1994,372(6505 ) :425 - 432.
3PELLEYMOUNTER M A, CULLEN M J,BAKET M B,et al. Effects of the obese gene product on boby weight regulation in ob/ob mice [ J ] . science, 1995,269 ( 5223 ) : 540 - 543.
4HALAAS J L, GAJIWALA K S, MAFFEI M, et al. Weight - reducing effecrs of the plasma protein encoded by the obese gene [j ]. Science, 1995,. 269 (5223) : 543 - 546.
5COMPFIELD L A , SMITH F L,GUISEZ Y,et al. Recombinant mouse ob protein :evidence for a peripheral signal linking adiposity and central neural netwoks [ J ] . science, 1995,269(5223) :546 - 549.
6HARWEY J, MCKENNA F, HETSON P S, et al.Leptin actiwates ATP - sensitive potassium channels in the rat insulin - secreting cell line CRI - G[ J ]. J physiol , 1997, 504(Pt 3) :527.
二级参考文献7
1Maffei M, Halaas J, Ravussin E et al. Leptin Levels in human and rodent - measurement of plasma Leptin and ob RNA in obese and weight - redeced subjects. Nature Med 1995, 1:1155.
2Ma Z, Gingerich RL, Santiago JV et al. Radioimmunoassay of Leptin in human plasma Clin Chem 1996, 42:942.
3Imagawa K, Matsumoto Y, Numata Y et al. Development of a sensitive ELISA fo human leptin, using monoclonal antibodies. Clin Chem 1998,44:2165.
4Masuzaki H, Ogawa Y, Nizawa Abe M et al. Glucose metabolism and insulin sensitivity in transgenic mice o overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity - associated diabetes. Diabetes1999, 48: 1615.
5Richard PD, Maximilian DC, Ronald JP et al. Is pasting leptin associated with insulin resistance among nondiabetic indivi- duals Diabites care 1999, 22:1092.
6Cunningham M J, Clifton DK, Steiner RA. Leptins actions on the reproductive axis: Prespectives and mechanisms Bio Reprod 1999,60:216.
4Bravo PE,Morse S,Borne DM,et al.Leptin and hypertension in obesity.Vase Health Risk Manag,2006,2(2):163-169.
5Correia ML,Haynes WG.Leptin,obesity and cardiovascular disease.Current opinion in nephrology and hypertensions,2004,13(2):215-223.
6Ren J.Leptin and hyper leptin emia-from friend to foe for cardiovascular function.The journal of endocrinology,2004,181(1):1-10.
7Tsochatzis E,Papatheodoridis GV,Archimandritis AJ.The evolving role of leptin and adiponectin in chronic liver diseases.Gastroenterol,2006,101(11):2629-2640.
8Ockenga J,Tietge UJ,Boker KH,et al.Distinct roles of free leptin,bound leptin and soluble leptin receptor during the metabolic in flammatory response in patients with liver cirrhosis.Aliment Pharmacol Ther,2007,25(11):1301-1309.
9Siddiqui AR,Abbas ZA.Leptin and liver disease:facts and presumptions.Journal of the college of physicians and Surgeons-Pakistan,2004,14(2):122-124.
10Li MG,Ding GL,Chen XJ,et al.Association ofserum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome.J Clin Endocrinol Metab,2007,92(12):4771-4476.