致耐受树突状细胞与移植免疫耐受

Tolerogenic dendritic cells and immune tolerance in grafts

致耐受树突状细胞（tolerogenic dendriticcell，Tol DC）有多种细胞亚型，在诱导移植外周免疫耐受中起重要作用。不同来源DC以及DC的不同成熟阶段都可能有致耐受特性。Tol DC诱导免疫耐受的机制主要与T细胞无能或凋亡、Treg细胞增殖和Th1／Th2细胞偏移有关。已有多种方法体外获得Tol DC。

Tolerogenic dendritic cells（Tol DC）, which have different subsets, have a dominant role in the induction of allograft peripheral tolerance. Different DC subsets can possess the potency of the tolerogenic properties. The tolerogenic function of DC involves various mechanisms, including induction of T-cell aner- gy, T-cell apoptosis, immune deviation, and generation of regulatory cells. Different strategies to generate tolerogenic DCs in vitro have been described in recent literatures.