摘要
5-羟色胺(5-HT)是一种内源性的活性物质,5-HT具有多种受体亚型。在中枢可以通过2A受体引起抑制性神经递质γ-丁氨酸(GABA)等的释放,从而发挥镇痛作用;在外周参与伤害性感受器的活化,促进伤害性信息的传递。组织损伤以及炎症状态下,血小板和肥大细胞即释放5-HT。5-HT2A受体可介导5-HT引起的疼痛,该受体可以作为开发外周镇痛药物的重要靶点。
5-hydroxytriptamine（5-HT） is an endogenous bioactive substance and its receptor has many subtypes including 5-HT2A.In the central,5-HT can induce the release of inhibitory neurotransmitter γ-aminobutyric acid（GABA） etc.through 5-HT2A receptor resulting in analgesia.In the peripheral,5-HT can active the nociceptor and advance the traumatic information transmission.5-HT can be released from the platelets and mast cells under the injured and inflammatory conditions.The 5-HT2A receptor subtype is involved in the 5-HT-mediated nociceptive mechanism,which can be researched as a target in exploring peripheral antinociceptive medication.
出处
《国际病理科学与临床杂志》
CAS
2007年第5期456-460,共5页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(30570600)~~
关键词
5-羟色胺受体
外周
中枢
致痛
镇痛
5-HT2A receptor
peripheral
central
nociception
antinociception
