血清AFP、AFU、CEA联合检测对原发性肝癌诊断的临床价值

Diagnostic Value of Serum AFP, AFU, and CEA in Primary Hepatic Cancer

目的探讨血清甲胎蛋白(AFP)、a-L-岩藻糖苷酶(AFU)、癌胚抗原(CEA)联合检测对原发性肝癌诊断的诊断价值。方法正常健康对照组84例,原发性肝癌组69例,肝炎肝硬化组44例,均同时检测血清AFP、AFU、CEA。结果原发性肝癌组血清AFP、AFU、CEA与肝硬化组、正常健康对照组比较,差异有统计学意义(P<0.01)。原发性肝癌组血清AFP、AFU、CEA单独检测时的敏感性分别为71.0%、81.2%和26.1%,联合检测AFP和AFU或CEA可使检测敏感性提高到87.0%和77.0%,三者联合检测敏感性为92.8%,血清AFP阴性标本AFU、CEA的敏感性分别为55.0%和25.0%。结论联合检测AFP、AFU和CEA3项指标可以大大提高原发性肝癌尤其是AFP阴性的诊断率。

Objective To evaluate the .diagnostic value of the combined examination of serum alpha fetal protein （AFP）, alpha-L-fucosidase （AFU）, and carcinoembryonic antigen （CEA） in patients with primary hepatic cancer （PHC）. Methods The serum levels of AFP, AFU and CEA were determined in 69 patients with PHC, 84 patients with liver cirrhosis, and 44 control subjects. Results Serum levels of AFP, AFU, and CEA in patients with PHC were all significantly higher than the control subjects and the patients with liver cirrhosis （P〈0.01）. The accuracy of diagnosis of PHC was 71.0%, 81.2%, and 26.1% respectively, when AFP, AFU, and CEA was individually examined. The accuracy could be increased to 87% （AFP and AFU） and 77% （AFP and CEA）. The accuracy was further increased to 92.8% when all AFP, AFU, and CEA were examined. Conclusion Combined examination of serum AFP, AFU and CEA is essential in the diagnosis of PHC, especially in AFP negative patients.