摘要
目的:比较托吡酯(TPM)与传统抗癫痫药丙戊酸(VPA)、卡马西平(CBZ)对新诊断男性癫痫患者垂体-性腺轴的影响。方法:采用自身前后对照方法。将54例男性癫痫患者随机分为TPM组和传统AED s组,分别给予TPM,VPA,CBZ单药治疗,于用药前和用药后6月观察雌二醇、孕激素、总睾酮、黄体生成素、卵泡刺激素、催乳素的改变,以探讨AED s对垂体-性腺轴的影响。结果:TPM组用药后6月较用药前催乳素明显下降,黄体生成素明显升高(P<0.05),VPA组卵泡刺激素显著下降(P<0.01),CBZ组黄体生成素明显升高(P<0.05)。TPM-CBZ组、VPA-CBZ组组间比较催乳素改变明显(P<0.05)。结论:AED s对癫痫患者的垂体-性腺轴均有一定影响,TPM主要影响垂体激素,可能与其抗癫痫作用机制有关。
Objective: To study the effects of antiepileptic drugs (AEDs), topiramate (TPM) and the traditional drugs [valproic acid (VPA) and carbamazepine (CBZ)], on pituitary-gonad axis in male patients with newly diagnosed epilepsy. Methods: In a randomized, controlled and self-controlled study, 54 male patients with newly diagnosed epilepsy were treated with TPM, VPA or CBZ. The baseline and post-treatment levels of serum dihydroxyestrin ( E2), progestogen ( P), total testosterone( TT), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) were measured, respectively, before and 6 months after treatment. Results: TPM treatment for 6 months significantly decreased PRL and increased LH level (P 〈 0.05) ; VPA deceased FSH level (P 〈 0.01 ) ; CBZ increased LH level (P 〈 0.05) in the serum. There were significant differences in PRL levels between VPA-CBZ and between TPM-CBZ groups (P 〈 0.05). Conclusion: AEDs can affect the pituitary-gonad axis in male epileptic patients. TPM mainly affects pituitary hormone, which may relate to its antiepileptie mechanism.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第22期1898-1900,1903,共4页
Chinese Journal of New Drugs
关键词
托吡酯
丙戊酸
卡马西平
垂体-性腺轴
topiramate
valproic acid
carbamazepine
pituitary-gonad axis