期刊文献+

托吡酯与传统抗癫痫药对男性癫痫患者垂体-性腺轴的影响比较 被引量:1

A comparative study for the effects of topiramate and traditional antiepileptic drugs on pituitary-gonad axis in male patients with newly diagnosed epilepsy
下载PDF
导出
摘要 目的:比较托吡酯(TPM)与传统抗癫痫药丙戊酸(VPA)、卡马西平(CBZ)对新诊断男性癫痫患者垂体-性腺轴的影响。方法:采用自身前后对照方法。将54例男性癫痫患者随机分为TPM组和传统AED s组,分别给予TPM,VPA,CBZ单药治疗,于用药前和用药后6月观察雌二醇、孕激素、总睾酮、黄体生成素、卵泡刺激素、催乳素的改变,以探讨AED s对垂体-性腺轴的影响。结果:TPM组用药后6月较用药前催乳素明显下降,黄体生成素明显升高(P<0.05),VPA组卵泡刺激素显著下降(P<0.01),CBZ组黄体生成素明显升高(P<0.05)。TPM-CBZ组、VPA-CBZ组组间比较催乳素改变明显(P<0.05)。结论:AED s对癫痫患者的垂体-性腺轴均有一定影响,TPM主要影响垂体激素,可能与其抗癫痫作用机制有关。 Objective: To study the effects of antiepileptic drugs (AEDs), topiramate (TPM) and the traditional drugs [valproic acid (VPA) and carbamazepine (CBZ)], on pituitary-gonad axis in male patients with newly diagnosed epilepsy. Methods: In a randomized, controlled and self-controlled study, 54 male patients with newly diagnosed epilepsy were treated with TPM, VPA or CBZ. The baseline and post-treatment levels of serum dihydroxyestrin ( E2), progestogen ( P), total testosterone( TT), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) were measured, respectively, before and 6 months after treatment. Results: TPM treatment for 6 months significantly decreased PRL and increased LH level (P 〈 0.05) ; VPA deceased FSH level (P 〈 0.01 ) ; CBZ increased LH level (P 〈 0.05) in the serum. There were significant differences in PRL levels between VPA-CBZ and between TPM-CBZ groups (P 〈 0.05). Conclusion: AEDs can affect the pituitary-gonad axis in male epileptic patients. TPM mainly affects pituitary hormone, which may relate to its antiepileptie mechanism.
出处 《中国新药杂志》 CAS CSCD 北大核心 2007年第22期1898-1900,1903,共4页 Chinese Journal of New Drugs
关键词 托吡酯 丙戊酸 卡马西平 垂体-性腺轴 topiramate valproic acid carbamazepine pituitary-gonad axis
  • 引文网络
  • 相关文献

参考文献13

  • 1HERZOG AG. Altered reproductive endocrine regulation in men with epilepsy: implication for reproductive function and seizures [ J ]. Ann Neurol,2002,51 ( 5 ) :539 - 542.
  • 2HERZOG AG, FOWLER KM. Sexual hormones and epilepsy: threat and opportunities [ J ]. Curr Opin Neurol, 2005,18 ( 2 ) : 167 - 172.
  • 3QUIGG M, KIELY JM, JOHNSON ML,et al. Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy [ J ]. Epilepsia, 2006 , 47 ( 9 ) : 1452 - 1459.
  • 4GLAUSER T, BEN-MENACHEM E, BOURGEOIS B, et al. ILAE treatment guidelines : evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes[J]. Epilepsia,2006,47(7) :1094 - 1120.
  • 5OSSEMANN M, BRULS E, de BORCHGRAVE V,et al. Guidelines for the management of epilepsy in the elderly [ J]. Acta Neurol Belg ,2006,106 ( 3 ) : 111 - 116.
  • 6ISOJARVI JIT, PAKARINEN AJ, YLIPAILSAAYI PJ, et al. Serum hormones in male epileptic patients receiving anticonvulsant medication [ J ]. Arch Neurol, 1990,47 ( 6 ) :670.
  • 7MOTTA E. Epilepsy and hormones [ J ]. Neurol Neurochir Pol, 2000,33( Suppl 1 ) :S31 - S36.
  • 8MACPHEE GJ, LARKIN JG, BUTLER E, et al. Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication [ J ]. Epilepsia, 1988,29 (4) :468 -475.
  • 9FRANCESCHI M, PEREGO L, CAVAGNINI F,et al. Effects of long-term antiepileptic therapy on the hypothalamic-pituitary axis in man [ J]. Epilepsia, 1984,25 ( 1 ) :46 - 52.
  • 10GEISLER J, ENGELSEN BA, BERNTSEN H, et al. Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulfate and dehydroepiandrosterone sulfate in male epileptic patients [ J ]. J Endocrinol, 1997,153 ( 2 ) :307 - 312.

同被引文献2

引证文献1

二级引证文献2

;
使用帮助 返回顶部