柴胡桂枝汤相合方剂免疫调节作用的实验研究

Study on Immunization of Chaihu-Guizhi Tang

目的:观察柴胡桂枝汤、桂枝汤、小柴胡汤的免疫调节作用,以证实其合方中方与方间存在着功效的相加、协同或拮抗关系。方法:设柴胡桂枝汤、桂枝汤、小柴胡汤3个药物组和空白时照组,计算其对正常小鼠脾淋巴细胞转化率、迟发型变态反应的耳肿胀率、腹腔巨噬细胞吞噬鸡红细胞的吞噬百分率。结果:药物组与对照组比较均能增加正常小鼠的脾淋巴细胞转化率、小鼠腹腔巨噬细胞吞噬鸡红细胞百分率、小鼠迟发型变态反应(P<0.05),柴胡桂枝汤的免疫调节作用优于小柴胡汤、桂枝汤(P<0.05)。结论:桂枝汤和小柴胡汤的免疫调节作用具有协同关系。

Objective ： To observe the immunization of Chaihu - Guizhi Tang, Guizhi Tang and Xiao - Chaihu Tang, confirmed the combined, synergies or antagonistic relationship on the effection of immunization among those herbs. Method： To observe the effect of different herbs on mice by delayed hypersensitivity induced by DNFB（ DTH ） , proliferous reaction of splenocytes , swollen degree of ears of experimental miceand mouse Carbin clearance experiment. Result： Compareing with the contral group, experimental groups can relieve the swollen degree grossly, increased the function of mono nuclaer -macrophage and the proliferous reaction （P 〈 0.05 ）. The immunorepressive action of Chaihu - Guizhi Tang was better than Guizhi Tang and Xiao - Chaihu Tang （ P 〈 0.05 ）. Conclusion： Guizhi Tang and Xiao - Chaihu Tang have the synergies relationship on the effection of immunization.