川崎病患儿心型脂肪酸结合蛋白质量浓度变化及其与心功能关系探讨

The changes of serum heart-type fatty acid-binding protein and its clinical significance in children with Kawasaki disease

目的探讨心型脂肪酸结合蛋白(h-FABP)在川崎病(KD)患儿中的水平变化及其与心功能的关系。方法选择青岛市儿童医院2004-02—2006-11收治的KD患儿40例为研究对象,采用酶联免疫吸附法检测血清h-FABP;并行心脏彩超多普勒(UCG)检测冠状动脉内径及左室射血分数(LVEF)并进行分组。结果急性期血清h-FABP质量浓度明显高于恢复期(P<0.01);冠状动脉病变(CAL)组和非冠状动脉病变(NCAL)组血清h-FABP质量浓度对比差异显著(P<0.01);KD患儿血清h-FABP质量浓度与LVEF呈负相关(r=-0.35,P<0.05)。结论血浆h-FABP质量浓度能够反映KD患儿心肌损害的严重程度,与LVEF相结合可估计患儿病情及预后。

Objective To study the serum level of heart-type fatty acid- binding protein （h-FABP） in children with Kawasaki disease （ KD ） and the correlation between it and the ejection fraction （ LVEF ）. Methods The serum levels of hFABP were determined in the children with KD（ n = 40） by enzyme-linked immnoabsorbent assay,and the internal diameter of coronary artery and LVEF were measured by two-dimensional echocardiography. Results The h-FABP concentration in KD group at the acute stage was higher than that at the recovery stage（ P 〈0. 01 ）. The difference of the h-FABP concentration between CAL and NCAL groups was significant （ P 〈 0. 01 ）. The h-FABP concentration in KD group had negative correlation with LVEF（ r = - 0. 35, P 〈 0. 05 ）. Conclusion The serum concentration of h-FABP is closely related to the severity of myocardial damage in the children with KD.