摘要
目的:对蚕沙中生物碱成分进行分离纯化和结构鉴定。方法:应用大孔树脂、离子交换树脂、葡聚糖凝胶等多种柱层析手段分离纯化生物碱成分,用质谱和核磁等光谱方法确定化合物的结构。结果:从蚕沙总生物碱部位中分离得到3个生物碱化合物,根据ESIMS、氢谱和碳谱数据鉴定为1-脱氧野尻霉素(1)、fagomine(2)和3-epi-fagomine(3)。结论:1-脱氧野尻霉素、fagomine和3-epifagomine均为首次从蚕沙中分离得到。
Objective: To extract and isolate chemical constituents from the total alkaloids of silkworm dropping(Can Sha)of Bombyx mori L..Methods: Chemical constituents were isolated by column chromatography with macroporous adsorbent resin,ion-exchange resin and sephadex LH 20.The structures of the isolated compounds were determined by spectral means.Results: Three compounds were isolated and identified as 1-deoxynojirimycin(1),fagomine(2),and 3-epifagomine(3) on the basis of their 1H-NMR,13C-NMR spectra and ESIMS data.Conclusion: Compounds 1-3 are isolated and identified from Can Sha for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2007年第11期1384-1385,共2页
Journal of Chinese Medicinal Materials