肝病患者血清中细胞因子TNF和IL-8的表达及其意义

Detection and significance of tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8) in serum with hepatosis

目的:观察肝病患者血清中的细胞因子TNF-α和IL-8的含量变化及其临床意义。方法:用ELISA法检测肝病患者与正常人血清中TNF-α和IL-8的浓度。结果:肝病患者血清中TNF-α和IL-8浓度明显增高,并在不同程度病变中改变不同。结论:肝病时细胞因子TNF-α和IL-8含量增高,增高程度与病情严重程度有关,可作为观察病毒性肝炎病情发展的动态指标,对临床肝病的治疗有一定的帮助。

Objective： TostudythechangesandsignificanceofTNF-αandIL-8inserumwithhepatitis.Methods： ThelevelsofTNF-αandIL- 8 in serum of patlent hepatitis and heahhy people were detected with ELISA. Results： The TNF-α and IL - 8 levels in patient hepatitis are obviously higher than that in healthy people and their changes are different in different degree damage. Conclusion： The TNF -α and IL - 8 heightened in patient hepatitis and their changes have relevant with the serious of the hepatitis. We can judge the development of the hepatitis accoding to the changes of TNF -α and IL - 8.