新生儿呼吸机相关性肺炎抗生素降阶梯疗法的疗效观察

The Effect of De-escalation Therapy of Antimicrobial Agents on the Treatment of Ventilator Assoeiated Pneumnonia

目的评价新生儿呼吸机相关性肺炎(VAP)采用抗生素降阶梯疗法的疗效。方法分析了40例VAP患儿。治疗组17例用抗生素降阶梯疗法,与常规组比较疗效。结果一次撤机成功率治疗组大于常规组(P<0.01),平均通气时间及通气>1周者,治疗组(6.1天)短于、少于常规组(10.3天)(P<0.01)。结论抗生素降阶梯疗法对VAP具有良好疗效。

Objective To evaluate the effect of de - escalation therapy of antimicrobial agents on the treatment of ventilator assoeiated pneumnonia （ VAP）. Methods 40 VAP patients were evaluated. 17 cases were treated by de - escalation therapy of antimicrobial agents, the rest were treated by routine therapy. Results The achievement ratio of machine removing was superiorer to that of routine therapy （P 〈0.01 ）. Patients （average duration of ventilation 〉 1 week） received deescalation therapy of antimicrobial agents whose average duration of ventilation was shorter than that treated by routine therapy （P 〈 0.01 ）. Conclusions de - escalation therapy of antimicrobial agents has well curative effect on VAP.