高血压微量蛋白尿患者的动态血压分析

The comparison on ambulatory blood pressure of essential hypertension with microalbuminuria

目的了解高血压微量蛋白尿患者动态血压特点。方法用放免法测定所有患者的尿微量白蛋白,根据结果将高血压患者分为微量蛋白尿组和无微量蛋白尿组。所有患者行24h动态血压监测。结果高血压微量蛋白尿患者昼夜节律消失率、24hSBP、NSBP、24hPP、NPP、NMBP明显高于单纯高血压组,差异有统计学意义(P<0.05);而DSBP、24hDBP、DDBP、NDBP、DPP、24hMBP、DMBP差异则无统计学意义(P>0.05)。结论高血压微量蛋白尿患者正常的杓型动态血压节律消失较明显,收缩压负荷、夜间收缩压升高明显,收缩压在早期肾损伤具有更重要的作用。ABPM在评价高血压肾脏靶器官损害方面有较好的预测价值。靶器官损害与血压节律异常可能有一定关系。

Objective To study the ambulatory blood pressure feature of essential hypertension with Microalbuminuria.Methods Microalbuminuria concentrations were detected by radioimmunoassay. Bassed on above results, the patients were divided into two groups：the Microalbuminuria group an the None Microalbuminuria group, and then 24hABPM were measured in the hypertensive patients. Results The rate Circaian rhythm disappearance of blood pressure,24hSBP,NSBP,24hPP, NBMP in the group of essential hypertension with Microalbuminuria were significantly high than that in the group of essential hypertension without Microalbuminuria, there have significantly difference（ P 〈 0.05） .however,there were no significantly diference（ P 〉 0.05） in DSBP,24hDBP, DDBP,NDB,DPP,24hMBP, DMBP. Conclusion Essential hypertension with Microalbuminuria patients have lost the normal dipper rhythm of ambulatory blood pressure obviously, especially rising in stress of SBP, NSBP. systolic blood pressure may play an important role in the earlier renal damage. ABPM was superior in predicting damage of target organ of kidney.