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S期激酶相关蛋白2在宫颈上皮内肿瘤和宫颈鳞状细胞癌中的表达及意义

The significance of Skp2 expression in cervical intraepithelial neoplasia and squamous cell carcinoma
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摘要 目的探讨S期激酶相关蛋白2(Skp2)在正常宫颈上皮、宫颈上皮内肿瘤(CIN)、宫颈鳞状细胞癌(SCC)中的表达及其在宫颈癌演进过程中作用和意义。方法用鼠抗人Skp2单克隆抗体,免疫组化两步法标记12例正常宫颈组织、30例宫颈上皮内肿瘤、30例宫颈鳞状细胞癌组织。结果正常宫颈组织、宫颈上皮内肿瘤和宫颈鳞状细胞癌Skp2表达阳性率分别为0%、76.6%、83.3%。正常宫颈组织与宫颈上皮内肿瘤、正常宫颈组织与宫颈癌Skp2的表达有显著差异(P<0.01)。而宫颈上皮内肿瘤与宫颈癌比较Skp2的表达无显著性差异(P>0.05)。结论Skp2参与了正常宫颈组织向宫颈上皮内肿瘤的演变,可能与宫颈鳞状细胞癌的发生和发展有关。 Objective To investigate the expression of S-phase kinase associated proteint 2 Skp2 and its significance in cervical intraepithelial neopIasia and squamous cell carcinoma. Methods The immunohistochemiscal staining was used to examine the expression level of Skp2 in samples of 12 cases of normal cervix, 30 cases of cervical intraepithelial neoplasia, and 30 cases of cervcal squamous cell carcinoma. Results The Skp2 expression rate in normal cervix, cervical intraepithelial neoplasia and cervcal squamous cell carcinoma was 0% ,76.6% ,83.3% ,respectivly. The rate of 76.6% and 83.3% was significantly higher than that of 0% in normal cervix ( P 〈 0. 01 ). But there was no significantly differecne in the expression of Skp2 between cervical intraepithelial neoplasia and cervcal carcinoma. Conclusion The increasing Skp2 expression involves in the development and progression from normal cervix to cervical intraepithelial neoplasia, and may be correlated to the onset and progress of cervical carcinoma.
出处 《滨州医学院学报》 2007年第6期404-406,共3页 Journal of Binzhou Medical University
关键词 S期激酶相关蛋白2 宫颈上皮内肿瘤 宫颈鳞状细胞癌 S-phase kinase associated proteint 2 ( Skp2) , cervical intraepithelial neoplasia, cervcal squamous cell carcinoma
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