摘要
目的了解大肠埃希菌(ECO)连续分离株整合酶基因阳性率和耐药性。方法应用聚合酶链反应法对56株大肠埃希菌连续分离株检测。结果56株ECO连续分离株中qacE△1—sul1基因阳性35株(62.5%)。结论在肠杆菌科细菌耐药机制中,Ⅰ类整合子起着非常重要的作用,整合子使细菌能够很快获得新的耐药基因以适应环境要求。鉴于qac基因在部分医院的高检出率,氯己定预防术后医院感染在我国需要重新评估。
Objective To investigate the presence of integrase gene in Escherichia coli consecutive isolates and the relation to bacteria resistance. Methods The Chlorhexidine-sulfadiazine-resistance (qacE△1-sul1) for 56 consecutive isolates of E, coli. were detected with polymerase chain reaction. Results 35 among 56 (62.5%) consecutive isolates were qacE △1-sul1 gene positive. Conclusions Class 1 Integron play a very important role in Enterobacteriaceae bacteria resistant mechanisms, bacteria can quickly acquire new resistance genes through integron to adapt new environments. For the high detection rate of qac gene in some hospitals, chlorine as rutine prevention of postoperative nosocomial infections need to be reassessed in China.
出处
《世界感染杂志》
2007年第6期461-463,共3页
World Journal of Infection
关键词
细菌耐药
大肠埃希菌
整合子
医院感染
bacteria resistant
Escherichia coli
integrons
nosocomial infections