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大肠埃希菌连续分离株耐药性及Ⅰ类整合子遗传标记的研究

Study on the relationship of class I integron and the resistance of Escherichia coli consecutive isolates
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摘要 目的了解大肠埃希菌(ECO)连续分离株整合酶基因阳性率和耐药性。方法应用聚合酶链反应法对56株大肠埃希菌连续分离株检测。结果56株ECO连续分离株中qacE△1—sul1基因阳性35株(62.5%)。结论在肠杆菌科细菌耐药机制中,Ⅰ类整合子起着非常重要的作用,整合子使细菌能够很快获得新的耐药基因以适应环境要求。鉴于qac基因在部分医院的高检出率,氯己定预防术后医院感染在我国需要重新评估。 Objective To investigate the presence of integrase gene in Escherichia coli consecutive isolates and the relation to bacteria resistance. Methods The Chlorhexidine-sulfadiazine-resistance (qacE△1-sul1) for 56 consecutive isolates of E, coli. were detected with polymerase chain reaction. Results 35 among 56 (62.5%) consecutive isolates were qacE △1-sul1 gene positive. Conclusions Class 1 Integron play a very important role in Enterobacteriaceae bacteria resistant mechanisms, bacteria can quickly acquire new resistance genes through integron to adapt new environments. For the high detection rate of qac gene in some hospitals, chlorine as rutine prevention of postoperative nosocomial infections need to be reassessed in China.
出处 《世界感染杂志》 2007年第6期461-463,共3页 World Journal of Infection
关键词 细菌耐药 大肠埃希菌 整合子 医院感染 bacteria resistant Escherichia coli integrons nosocomial infections
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  • 1陈升汶,卢月梅,张阮章,王沙燕,何林,穆雪鵾.大肠埃希菌和肺炎克雷伯菌超广谱Β内酰胺酶基因分型研究[J].中华检验医学杂志,2006,29(2):166-167. 被引量:44
  • 2宁永忠,王辉,孙宏莉,朱任媛,刘振英,张捷.大肠埃希菌和肺炎克雷伯菌产生的超广谱β-内酰胺酶和质粒AmpC型β-内酰胺酶的分子流行病学研究[J].中华微生物学和免疫学杂志,2006,26(10):944-949. 被引量:35
  • 3Dalsgard A, Forslund A, Serichantalergs O, et al. Class 1 integrons in different Vibrio cholerac 0-sertype strains isolated in Thailand[J]. Antimicrobial Agents and Chemotherapy, 2000, 44(5): 1315-1321.
  • 4Kang SG, Lee DY, Shin SJ, et al. Changes in patterns of antimicrobiol susceptibility and class 1 integron carriage among Escherichia coli isolates[J]. J Vet Sec, 2005, 6(3): 201-205.
  • 5Gaze WH, Abdouslam N, Hawkey PM, et al. Incidence of Class 1 Integrons in a Quaternary Ammonium Compound-Polluted Environment[J]. Antimicrob Agents Chemother, 2005, 49(5): 1802-1807.
  • 6Poirel L, Brinas L, Verlinde A, et al. BEL-1, a Novel Clavulanic Acid-Inhibited Extended-Spectrum B-Lactamase, and the Class 1 Integron In120 in Pseudomonas aeruginosa[J]. Antimicrob Agents Chemother, 2005, 49(9): 3743-3748.
  • 7Essa AM, Julian DJ, Kidd SP, et al. Mercury resistance determinants related to Tn21, Tn1696, and Tn5053 in enterobacteria from the preantibiotic era[J]. Antimicrob Agents Chemother, 2003, 47(3): 1115-1119.
  • 8莫晓能,李建国,唐英春,张永,朱家馨,谈淑卿,陆坚.主动外排系统在耐甲氧西林金黄色葡萄球菌多重耐药中的作用[J].中华结核和呼吸杂志,2007,30(1):40-43. 被引量:28
  • 9Segers P, Speekenbrink RG, Ubbink DT, et al.Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial[J]. JAMA, 2006, 296(20): 2460-2466.
  • 10Ho KM, Litton E. Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis[J]. J Antirnicrob Chemother, 2006, 58(2): 281-287.

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