sTn抗原和CA242、CA19-9及CEA联合检测对胃肠道肿瘤的诊断价值

Application Value of Combined Measurement of Serum sTn,CA242,CA19-9 and CEA in the Diagnosis of Gastroenterological Neoplasm

探讨血清肿瘤标志物糖链抗原sTn、糖链抗原242(CA242)、糖链抗原19-9(CA19-9)、癌胚抗原(CEA)对胃肠道肿瘤的诊断价值。采用RIA对30例健康成人和60例不同的胃肠道肿瘤患者血清进行测定。结果表明,胃癌和大肠癌患者血清sTn、CA242、CA19-9和CEA值均明显高于对照组(P<0.01).大肠癌组CEA、CA19-9和CA242浓度显著高于胃癌组(P<0.01),而sTn浓度显著低于胃癌组(P<0.01)。血清sTn、CA242、CA19-9和CEA的阳性率随临床分期的增加而增加,Ⅳ期阳性率显著高于Ⅰ～Ⅱ期(P<0.01)。四种肿瘤标志物联合检测.对胃癌的敏感性较单项显著提高(P<0.05);对大肠癌敏感性较单项CA19-9或sTn显著提高(P<0.05)。四种肿瘤标志物对于胃肠道肿瘤的诊断有一定意义,不同肿瘤标志物组合后可以提高胃癌的检出率。

To determine the application value of four serum tumor markers sTn, CA242, CA 19-9 and CEA in the diagnosis of gastroenterological neoplasm, the serum sTn, CA242, CA19-9 and CEA in 30 normal adult controls and 60 patients with gastroenterological neoplasm were measured by IRMA. The results showed that the serum sTn,CA242,CA19-9 and CEA levels in patients with gastric carcinoma or colorectal carcinoma were much higher than those in control group （P〈0.01）. The serum CEA, CA19-9 and CA242 levels in patients with colorectal carcinoma were significantly higher than those in patients with gastric carcinoma （P〈0.01）, but the serum sTn level in the former was markedly lower （P〈0.01） than that in the latter. The sensitivity of tumor marker increased with the progress of clinical stages, with a considerably higher sensitivity for stage Ⅳcompared with stage Ⅰ - Ⅱ（P〈0.01）. The combined test of four tumor markers could be more sensitive than single test in detecting gastric carcinoma and colorectal carcinoma （P〈0.05）. Four tumor markers are useful for diagnosing gastroenterological neoplasm, and the combined measurement of 4 tumor markers could increase the sensitivity of detecting gastric carcinoma.