疏血通注射液治疗紫癜性肾病100例临床分析

Clinical study of Shuxuetong injection in the treatment of nephrotic syndrome caused by anaphylactoid purpura

目的：探讨疏血通注射液治疗儿童过敏性紫癜（AP）引起的肾病综合征的临床疗效。方法：100例紫癜性肾病患儿随机分为治疗组和对照组，两组各50例。均以强的松中长程治疗。治疗组同时应用疏血通注射液21d，观察4—6周并随访。治疗前后分别测量血脂、肾功能、血流变学等各项有关指标，并记录治疗后两组患儿血压、浮肿、蛋白尿、血尿、β2-MG恢复正常的时间。结果：治疗组治疗前后及两组治疗后尿素氮、肌苷、胆固醇、甘油三脂、血浆粘度、血小板聚集率及红细胞电泳时间比较差异有统计学意义（P〈0．05）；两组的红细胞压积比比较差异无统计学意义（P〉0．05）；血沉下降，两组间差异无统计学意义（P〉0．05）；血压、浮肿、蛋白尿、血尿、β2-MG恢复正常的时间治疗组和对照组比较有统计学意义（P〈0．05）。结论：疏血通注射液治疗紫癜性肾病疗效好，能缩短病程，提高治愈率，值得临床推广应用。

Objection To investigate the therapeutic effect of Shuxuetong injection in the treatment of nephrotic syndrome caused by anaphylactoid purpura （AP）. Method One hundrand children suffering from nephrotic syndrome caused by AP were divided into two groups as the experimental group and the control group randomly, with 50 cases in each group. The two groups were both treated with prednisene and additional treatment of Shuxuetong were administrated in the experimental group for 21 days. The two groups were followed up for 4 - 6 weeks. Changes of blood lipid, renal function and hemorheology were detected by relevant methods and the time spans of symptoms such as blood pressure, edema, albuminuria, bematuria and microglobulin became normal were registered. Results Blood urea nitrogen, inosine, cholesterol, triglyceride, blood viscosity, platelet aggregation rate and erythrocyte electrophoresis time showed significant difference between the two groups after treatment and pre - and post - treatment in the experimental group （P 〈 0.05）, while the differences of the packed cellvolume and erythrocutes sedimentation rate between the two groups had no statistic meanings （ P 〉 0.05 ）. The differences of recovery time in the two groups were significant （ P 〈 0.05 ）. Conclusion Shuxuetong injection is effective in the treatment of nephrotic syndrome caused by AP by improving the curative rate and lessening hospitalized time.