摘要
目的:考察2家企业生产六神丸中蟾蜍二烯内酯类化合物的含量。方法:采用高效液相色谱法/DAD检测器同时测定4种蟾蜍二烯内酯类化合物。结果:该测定方法的回收率高于96%,线性范围在1μg/mL^100μg/mL,方法重现性良好。六神丸标准方中的蟾蜍二烯内酯含量显著高于在其他配伍方式样品中含量。结论:六神丸配伍均匀程度可能对蟾蜍二烯内酯类化合物具有一定的增溶作用,促进了这种活性物质的释放。
AIM： To investigate the concentration of bufadienolides in Liushen Pill from two enterprises. METHODS： Four kinds of bufadienolides were simultaneously determined by using HPLC with DAD detector. RESULTS： Recoveries obtained from the four kinds of bufadienolides were higher than 96%, the linearity was in the range of 1μg/mL - 100 μg/mL. The concentration of bufadienolides in Liushen Pill was significantly higher than that in other related TCM compatibilities. CONCLUSION： The well-distributed compatibility in Liushen Pill has an influence on the solubilization of bufadienolides, may be in relation to eahancing to release.
出处
《中成药》
CAS
CSCD
北大核心
2008年第1期64-67,共4页
Chinese Traditional Patent Medicine
基金
国家科技攻关计划(2004BA721A13)
