山莨菪碱及地塞米松对MODS时微循环及免疫病理学改变的实验研究

The effect of anisodaminum and dexamethasone on microcirculation, TNF, LPO and pathology in MODS

为了解山莨菪碱及地塞米松对兔多器官功能障碍综合征（ＭＯＤＳ）时微循环变化及对肿瘤坏死因子（ＴＮＦ）、脂质过氧化物（ＬＰＯ）和病理改变的影响，作者将日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）造成腹腔感染，制成ＭＯＤＳ动物模型，随机分为山莨菪碱组、地塞米松组、山莨菪碱及地塞米松组、对照组，用药后观察微循环的变化、ＴＮＦ、ＬＰＯ的变化和组织器官的病理形态学改变。结果显示用药后微循环的灌注量、微循环内红细胞等移动的微粒数量明显增加，实验各组血浆的ＴＮＦ及ＬＰＯ水平均有明显的降低，器官形态学变化较对照组均有不同程度的减轻。以联合用药组变化最突出。提示山莨菪碱及地塞米松联合应用可能是ＭＯＤＳ时改善微循环和抗细胞因子、抗氧自由基治疗的新途径。

In order to evaluate the effect of anisodaminum and dexamethasone to the microcurculation, TNF, LPO and pathology in MODS, we first established MODS model using cecem ligature and perfuration of rabbit then divided it into four groups: anisodaminum, dexamethasone, combined anisodaminum and dexamethasone and control. After used the corresponding drugs we observed the change of microcirculation, TNF, LPO and organ pathology. The result showed that microcirculation improved,the serum level of TNF and LPO decreased, and the pathomorphological changes lessensed. It is suggested that the combined use of anisodaminum and dexamethasone may be a new way for treating MODS.