NAD(P)H辅酶模型在Mg^(2+)离子催化条件下还原N-芳基芴亚胺反应的研究

Studies on the Mg^(2+)-Catalyzed Reductions of N-Arylfluorenimines by NAD(P)H Models

对Hantzsch酯在Mg(2+)存在和不存在的情况下还原N-芳基芴亚胺的反应进行了研究，并与BNAH的类似还原做了系统的比较．研究结果表明：Mg(2+)在该还原反应中起亲电催化剂的作用；还原能力较BNAH弱的Hantzsch酯在反应中所呈现的强的反应性是由于其3，5-位两个极性谈基氧通过静电作用降低过渡态的能量的缘故；本文反应届H-一步转移机理．

The reductions of N-arylfluorenlmines by Hantzsch ester in the presence andabsence of Mg2+ have been studied. The similar reductions by BNAH have been compared.The results show that (1) Mg2+ plays a role of electrophilic catalyst; (2) the strongerreduction ability of Hantzsch ester than BNAH Is the result of electrostatic effect caused by its3,5-carbonyl oxygens which decreases the energy of the transition state more effectively;(3) one-step hydride transfer mechanism has been proposed.