新抗生素波拉霉素 A 和 B 的结构测定

STRUCTURE DETERMINATION OF NEW ANTIFUNGAL ANTIBIOTICS, POLARAMYCINS A AND B

从一株吸水链霉菌（Ｓｔｒｅｐｔｏｍｙｃｅｓｈｙｇｒｏｓｃｏｐｉｃｕｓ）ＬＰ９３的培养物中分离到新抗真菌抗生素—波拉霉素Ａ和Ｂ。它们属于多羟基大环内酯抗生素。基于光谱数据（ＵＶ，ＩＲ，１ＨＮＭＲ，１３ＣＮＭＲ，ＤＥＰＴ，１Ｈ１ＨＣＯＳＹ，ＨＥＴＣＯＲ，ＨＭＢＣ）波拉霉素Ａ和Ｂ的结构阐明如图１，其中波拉霉素Ａ，Ｒ＝Ｈ；波拉霉素Ｂ，Ｒ＝ＣＨ３。

Antifungal antibiotics, polaramycins A and B have been isolated from the culture of Streptomyces hygroscopicus LP 93. Polaramycins A and B are 36 membered polyol macrolide antbiotics containing hemiacetal monoester of malonic acid and guanidyl groups. Based on spectral evidence including UV, IR, FABMS, 1HNMR, 13 CNMR, DEPT, 1H 1H COSY, HETCOR, HMBC, the structure of polaramycins A and B have been assigned as shown in Fig 1 (A, R=H; B, R=CH 3).