机体在应激状态下5-羟色胺水平分析

Horizontal Analysis of 5-Hydroxytryptamine in Stress Condition

目的:探讨机体在应激状态下血清中5-羟色胺(5-HT)水平的变化。方法:采用酶联免疫吸附法分别对64例参加军事演习的官兵(研究组)演习前后和59例抑郁症患者(对照组)进行血清5-HT含量测定。结果:研究组演习前血清5-HT含量为(0.85±0.17)μmol/L,演习结束后血清5-HT含量为(0.64±0.11)μmol/L,演习后5-HT水平明显低于演习前(P<0.05);对照组血清5-HT含量为(0.52±0.14)μmol/L,与研究组演习前比较明显偏低,差异有显著性意义(P<0.05),与研究组演习后比较,差异无显著性意义(P>0.05)。结论:军事演习应激情况下及发生精神疾病时血清单胺类神经递质5-HT均可发生不同程度的改变,在应激状态下定期检测5-HT血清含量是预防精神疾病发生的一种重要手段。

Objective：To probe into 5-hydroxytryptamine （5-HT）horizontal variety in stress condition and depression outbreak. Methods： Eenzyme Linked Immunosorbent Assay（ELISA） was used to test the assaying of Serum 5-HT in 64 officers and soldiers who took part in a military exercise（ the study group） and 59 patients of depressive disorder（ the control group ）. Results： The assaying of Serum 5-HT in the study group was（0. 85± 0. 17 ）μmol/L before the exercise and was lower than that after the exercise（0. 64± 0.11 ）μmol/L（ P 〈 0. 05 ）. But the assaying of the control group was （0.52 ± 0. 14 ） μmol/L, which was obviously lower than that of tile study group befure the exercise with a significant difference（P 〈 0. 05 ）. Conclusion：The plasma monoamine neurotransmitter 5-HT may have different changes when psychological disorders happen in a stress situation during a military exercise. It is an important method to assay the content of 5-HT in a stress state to prevent psychological disorders.