摘要
采用Taqman PCR法探讨糖基化终产物受体(RAGE)基因G1704T多态性与糖尿病肾病的相关性。结果发现RAGE基因1704T等位基因频率在糖尿病肾病中显著增高(P<0.05),由此推测RAGE基因1704T等位基因可能是糖尿病肾病发生的危险因素。
The association of G1704T polymorphism of RAGE gene with diabetic nephropathy in type 2 diabetes was observed by Taqman PCR. The GT+TT genotype frequencies and T allele frequencies in DN group were significantly higher than those in DM(P〈0. 05). The RAGE gene T-positive genotypes may be the risk factor for the development of diabetic nephropathy in type 2 diabetes.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2008年第1期21-22,共2页
Chinese Journal of Diabetes
基金
云南省教育厅科研基金(5Y0416C)
关键词
受体
糖基化终产物
糖尿病
2型
遗传学
糖尿病肾病
Receptors, advanced glycation end products
Diabetes mellitus, type 2
Genetics
Diabetic nephropathy