补骨脂主要炮制品的毒性比较

Toxic Studies on Various Processed Products of Fructus Psoraleae

对补骨脂及其主要炮制品的毒性进行了比较研究。生品对小鼠口服的LD_(50)为37.71±0.54g/kg,盐炙品为43.25±6.1g/kg。连续口饲小鼠14天,在5.0g/kg剂量时,生品和清炒品引起睾丸、包皮腺、前列腺、精囊腺重量显著下降。雷公法泡制品对包皮腺、前列腺、精囊腺,盐蒸品对精囊腺和前列腺的重量亦有不同程度抑制。生品还可明显引起肾小球上皮细胞增生和肾小管浊肿。

Toxic studies on Fructus Psoraleae (FP) and its processed products are carried on. LD50 is 37. 7± 0. 54 g crude drug/kg in oral admimistration of raw FP in comparison with 43. 25 ± 6. 1/kg in that of Salt-bake one in mice. When 5. 0g/kg is given by oral for 14 days,the wet weight of testicles,preputial galnds,prostate and semi-anl vesicle is decreased in raw FP and its stir-bake tested groups. The wet weight of preputial glends,prostate,seminal ves,icle in Lei Gong's Procession group,or prostate,and seminal vesicle in salt-steam group is also decreased to a certain extent. But no significant change on the weight of those sex organs is found in liquor-bake or salt-bake procession group,The glomerulal cell hyperplasia and cloudy swelling of renal tubules are induced by administration of raw FP in pathological examination.