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一种体内恒速持续给药的方法—微量渗透泵 被引量:5

A CONTINUOUS AND CONSTANT RATE ADMINISTRATION METHOD——MINI OSMOTIC PUMP
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摘要 利用微量渗透泵给药是一种崭新的动物实验性持续给药方法。泵体由3个同心层(由内向外)—贮药池、渗透性套筒及控制渗透泵药物释放速度的半透膜组成。泵在被水激活后,因水可按渗透梯度渗入渗透性套筒部分,压迫泵体以恒定速度持续释放药物几天至若干星期,其渗透速度与被释放药物的理化性质无关。 Mini osmotic pump is a delicate administration method. When it is activated by water, mini osmotic pump can deliver a variety of solutions or suspensions at a constant rate for days even up to several weeks. Since it is drived by osmotic pressure, the pumping rate is independent on the physical and chemical feature of the drugs. The pump from inside to outside consists of a cylindrical reservior, osmotic driving agent and semipermeable membrane.
出处 《中国应用生理学杂志》 CAS CSCD 1997年第3期278-280,共3页 Chinese Journal of Applied Physiology
关键词 微量渗透泵 恒速持续给药 动物实验 方法技术 mini osmotic pump continuous and constant rate administration
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