摘要
作者应用分子杂交法,研究肝细胞生长因子受体(c-met)mRNA在人肝细胞癌中的表达及其意义。Northern杂交分析结果表明:在癌组织中有16例c-met表达阳性,在癌周肝中有12例c-met表达阳性。c-met在肝细胞癌组织中与癌周肝组织中的表达阳性的例数差异无显著意义(P>0.05)。经统计学处理发现c-met和肝细胞癌分化程度、分期、大小、HBsAg、AFP、门静脉癌栓间无显著相关(P>0.05)。作者认为c-met基因可能在肝癌形成及转移过程中起调节作用。
Using Northern blot method,we examined the expression of c met in human hepatocellular cancer. Of 30 patients tested,the expression of c met mRNA was not significantly different in HCC tissues from corresponding noncancerous parenchyma( P >0 05).There was no significant relationship between c met expression and grade of differentiation,stage of clinic,AFP, HBsAg ( P >0 05). Our results suggest that c met may play different roles in the pathogenesis and metastasis of human hepatocellular carcinoma.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第5期305-306,共2页
Chinese Journal of Surgery
关键词
肝肿瘤
肝细胞癌
基因表达
肝细胞生长因子
Carcinoma,hepatocellular Gene expression Proto oncogenes Hybridization