鲍曼不动杆菌的临床分布及耐药性分析

Analysis of antibiotics resistance and distribution of clinical strains of acinetobacter baumannii

目的:调查鲍曼不动杆菌医院内感染分布特点及耐药性。方法:常规细菌培养方法,细菌鉴定采用美国Walk-away-40全自动细菌鉴定仪,药敏试验采用琼脂纸片扩散法。结果:鲍曼不动杆菌最常出现在痰标本中,占75.7%,其次是分泌物和尿液,鲍曼不动杆菌感染以病房为主,尤以重症监护病房(ICU)、神经外科病房最多,其次是普外科、呼吸科和门诊。该菌耐药现象严重,耐药率较低的抗菌药物是碳青霉烯类药物如亚胺培南、含酶抑制剂复合剂如特制星、舒谱深等。结论:鲍曼不动杆菌在临床的多重耐药呈上升趋势,因此对鲍曼不动杆菌进行规范的连续的耐药监测,及早发现耐药菌株,对调整治疗方案、预防院内感染的发生是非常重要的。

Objective：To investigate the clinical distribution and resistane of Acinetobacter baumanii.Methods：Routine bacteria culture and American Walkaway-40 identification system were adopted for bacteria identification.Susceptibility was tested by Kirby-Bauer method.Results：For specimen from which Acinetobacter baumanii were examined,sputum accounted for 75.7%.Then they were secretion and urine.Acinetobacter baumanii was mainly distributed at ICU ward and neurosurgery ward.The resistance of Acinetobacter baumanii was serious.The antibiotic drugs which had the low resistance ratio were carbapenems,b-lactam/b-lactamase inhibitor combinations.Conclusion：The infection of multi-drug resistant Acinetobacter baumanii.has ascending tendency.Therefore,monitoring Acinetobacter Baumanii constantly and regularly,finding out resistant strains timely and adjusting the treatment methods is very important for the prevention of nosocomial infection.