重症肺炎抗生素降阶梯疗法的疗效观察

Observation onthe efficacy of de-escalation therapy for severe pneumonia

目的观察采用抗生素降阶梯疗法治疗重症肺炎的疗效。方法60例重症肺炎患者随机分为观察组及对照组，观察组30例采用抗生素降阶梯疗法，对照组30例采用常规抗生素治疗，比较2组疗效。结果观察组病死率、ICU住院时间、总住院时间均低于对照组，差异均有统计学意义（均P〈0．05）；观察组机械通气时间低于对照组，差异有统计学意义（P〈0．01）。结论抗生素降阶梯疗法对重症肺炎具有良好的治疗效果。

Objective To investigate the efficacy of de-escalation therapy for severe pneumonia. Methods 60 patients with severe pneumonia were randomly divided into two groups. The treatment group （ n = 30 ） received antibiotic de-escalation therapy and control group （ n = 30 ） received antibiotic traditional treatment. The curative effects were evaluated after treatment. Results There were significant differences in mortality,the total duration in ICU ,the mechanical ventilation time and the total duration of hospitalization between the two groups（ P 〈0.05 ,P 〈 0.01 ）. Conclusion Antibiotic de-escalation therapy has a better effect on severe pneumonia.