持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征合并高血压的疗效观察

the effects of CPAP on BP in patients with OSAHS and hypertension

目的观察持续气道正压通气（CPAP）对于阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并高血压患者血压的治疗效果。方法选择1999-2005年于我科诊断为OSAHS并坚持CPAP治疗的61例男性患者作为研究对象，对其进行近期与远期回访。回访时测量患者血压，并进行多导睡眠呼吸监测（PSG）。结果1．A组患者收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）均较治疗前明显下降（P〈0．001）。2．A组和B组患者血压近期与远期比较没有明显差异。3．睡眠呼吸暂停低通气指数（AHI）、最长呼吸暂停时间（LAT）与血压呈正相关，最低血氧饱和度（MinSaO2）与血压呈负相关。结论1．应用CPAP可有效降低OSAHS合并高血压患者的血压；2．OSAHS合并高血压忠者CPAP持续治疗6个月其血压可得到有效控制，长期戴机可维持疗效，因此OSAHS合并高血压患者应坚持长期CPAP治疗。

Objectives To observe the effects of CPAP on BP in patients with OSAHS and hypertension. Methods 61 male patients were sel ected who were with OSAHS and had insisted treating with CPAP from 1999 to 2005. They were reviewed for two times. When reviewed patient s were measured BP and undertaken PSG. Results 1. A group showed a significant reduction in SBP, DBP and MAP（P〈0.001）.2. Of all patients t here is no statistics difference in BP between near and long -term future. 3.There is positive correlation between AHI, LAT and BP and negative correlation between MinSaO2 and BP. Conclusions 1.The long-term use of CPAP can efficiently lower BP of patients with OSAHS. 2. Continuo usly treated for 6 months,BP of OSAHS patients complicating hypertension can be controlled efficiently, long-term treating can maintain therapeutic effect, accordingly,patients with OSAHS and hypertension should insist long-term treating with CPAP.