摘要
目的:探讨四次甲基二砜四胺(TETS)所致精神障碍的临床特征,提高临床诊断水平,进而探讨TETS所致精神障碍的发生机制。方法:采用自编临床调查表,对28例TETS中毒所致精神障碍(研究组)和28例癫痫所致精神障碍(对照组)进行临床对照分析。结果:两组间出现幻听、幻视、感知综合障碍、被害妄想、夸大妄想、情感迟钝、阵发性兴奋和冲动、睡眠障碍、自知力缺乏、脑电图异常等症状发生率的差异无统计学意义(P>0.05);两组患者均在抽搐减少或抽搐停止后出现精神症状;研究组以急性起病为主,对照组以慢性起病为主,两组间差异有非常显著的统计学意义(P<0.01);恐惧12例和顺行性遗忘13例仅出现在研究组及思维松弛11例仅出现在对照组,两组间差异均有非常显著的统计学意义(P<0.01);研究组误诊5例。结论:两组病例的主要精神症状表现相同,但在起病形式及部分精神症状表现具有各自的特点;TETS所致精神障碍的发生机制与γ-氨基丁酸(GA-BA)有关。
Objective :To discuss the pathogenesis of mental disorder caused by TETS and improve the diagnostic precision by studying the clinical features of mental disorder caused by TETS. Methods :28 mental disorder inpatients caused by TETS poisoning (subject group) and 28 mental disorder cases caused by epilepsy (comparative group) were recnrited in the study. The self-designed questionnaires were applied to investigate the clinical features of the two groups. Results:The variations of symptom incidences of the two groups in the following symptoms such as auditory hallucination, heteroptics, comprehensive perception disorder, murdered deliria, exaggeration deliria, emotional inaction, spelled excitement and impulsion, sleep disorder, lack of self- knowledge ability and abnormal electroencephalogram, etc. , have no statistical significance( P 〉 0.05 ). Psychiatry symptoms occurred after the reduction and termination of tics in both groups. While acute attacks appear in the subject group, the comparative group has chronic attacks. The discrepancies of the two groups enjoy great statistical significance (P 〈0.01 ). 12 phobia cases and 13 direct amnesia cases occurred only in the subject group, while 11 cases of slackening thinking only in the comparative group. The distinctions of the two groups enjoy striking statistical significance (P 〈0.01 ). There are 5 erroneous diagnoses in the subject group. Conclusion:The two groups have identical major psychiatry symptoms, but their pathogenic forms and minor psychiatry symptoms show different features. The pathogenesis of mental disorder caused by TETS relates GABA.
出处
《赣南医学院学报》
2008年第1期15-16,21,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
四次甲基二砜四胺
癫痫
精神障碍
中毒
Γ-氨基丁酸
Tetramethylenedisulphotetramine (TETS)
Epilepsy
Mental disorder
Poisoning
Gamma - aminobutyric acid(GABA)